cis-trans test

cis-trans test
The complementation test with two or more interacting genes placed in cis and in trans relationships to each other. A double mutant genome is used in the cis test made from the two single mutant genomes used in the trans test by recombination. If the wild type phenotype is restored by both cis and trans arrangements it is concluded that the two mutations are in different genes and hence that the phenotype is determined by more than one gene. If the trans test is negative and the cis positive this means that the two mutations are in the same gene. If both tests are negative then at least one of the mutations must be dominant. Thus the double test provides a means of fine mapping of genes.

Dictionary of molecular biology. 2004.

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  • cis-trans-Test —   [lateinisch], Komplementationstest, Genetik: Test zur Feststellung, ob zwei Mutationen zwei verschiedener Allelen eines Gens oder zwei Genen zuzuordnen sind. Ein Genomabschnitt, der sich im cis trans Test als Funktionseinheit erweist, wird als… …   Universal-Lexikon

  • cis-trans-test — cis trans test. См. функциональный тест на аллелизм. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • cis-trans test — in microbial genetics, a test to determine whether two (recessive) mutations are alleles (located in the same gene) or pseudoalleles (located in different genes). A heterozygote carrying the mutations on the same chromosome (cis configuration)… …   Medical dictionary

  • cis-trans — [ sistrɑ̃s ] adj. • 1957; isomère cis trans 1933; de cis et trans ♦ Biol. Test cis trans : test permettant de connaître l effet de la configuration relative sur l expression de deux mutations chez un double hétérozygote. Isomérie cis trans. ● cis …   Encyclopédie Universelle

  • trans — transfer; transference; transverse * * * trans tran(t)s, tranz adj 1) characterized by or having certain groups of atoms on opposite sides of the longitudinal axis of a double bond or of the plane of a ring in a molecule see all trans 2) rela …   Medical dictionary

  • CIS — Abbreviation for carcinoma in situ. * * * capacity information system; carcinoma in situ; catheter induced spasm; central inhibitory state; Chemical Information Service; clinical information system; computer integrated surgery; computerized… …   Medical dictionary

  • cis- — ⇒CIS , élément préf. Élément préf. signifiant « en deçà de », formateur de composés subst. ou adj., princ. en géogr., en anat., chim. et phys. Anton. trans . A. GÉOGR. (v. aussi cisalpin, cismontain, cisrhénan empruntés au latin) : cisgangétique …   Encyclopédie Universelle

  • test — 1. To prove; to try a substance; to determine the chemical nature of a substance by means of reagents. 2. A method of examination, as to determine the presence or absence of a definite disease or of some substance in any of the fluids, tissues,… …   Medical dictionary

  • Cis AB — is a rare ABO Blood group antigen genotype which is phenotypically almost the same as AB. In Cis AB inheritance A and B antigen seem to be segregating as if they are in very close loci on the same chromosome. These can happen due to mutant… …   Wikipedia

  • Trans fat — Types of fats in food Unsaturated fat Monounsaturated fat Polyunsaturated fat Trans fat Cis fat Omega fatty acids: ω−3 ω−6 ω−9 Saturated fat Interesterified fat See also Fatty acid …   Wikipedia

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